the innate life review
The innate immune system is the first line of host defense against pathogens. A dominant paradigm being developed in immunotherapy for hematologic malignancies is of adaptive immunotherapy that involves chimeric antigen receptor CAR T.
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Host cells recognize pathogen-associated molecular patterns through pattern recognition receptors PRRs to initiate antimicrobial innate immune responses During viral infections host PRRs can recognize viral nucleic acids especially features conserved in viral RNA or DNA.
. This review describes the exploitation of approaches that trigger innate immune activation for adaptive immune cells to operate maximally in the tumor microenvironment of these lymphomas.
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